Endocrine Abstracts

Pancreatic ductal adenocarcinoma (PDA) remains a highly lethal malignancy. Therapeutic strategies aimed at targeting pancreatic cancer cells have failed. We hypothesized that such pitfall is due to the functional heterogeneity of this tumor which comprises both cancer and stromal cells. It is now recognized that cancer-induced but host-derived stromal events support tumor growth and chemoresistance. In order to reach efficacy with chemotherapies, we believe that stroma has to ...